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UnConference 2017

Exponential Medicine 2017 UnConference

2017 UNCONFERENCE

Tonight we'll host an "UnConference." This is a chance for attendees to lead an open discussion with their peers about a topic of their choice. Topics have been submitted over the past few days, and selected topics are listed below. The UnConference will begin at 9:00pm in the California Cabanas, and will consist of three rounds, each 15-20 minutes long, with up to 8 discussions happening simultaneously. The topics are:

Round One

Blue Sky Dreaming: Bringing Healthcare to Where the Patient Is

It's not a secret that patient's homes are the epicenter of their lives, for good and for bad. For some reason, we force them to receive care in centralized clinics and hospitals, removed from the intimacies of what makes patients sick and keeps them healthy. Finally, we have the technology to bridge this gap in holistic care by going to where the patient is, instead of demanding they come to us. What’s the best approach? How do we make medicine more personal on a house-by-house level, while keeping costs low? What technology exists? What technology is still desired?

I’ve worked with community health workers in the Amazon of Peru and conducted numerous house calls to sick children in the underserved neighborhood’s of Boston. Now I’m launching a technology driven startup aiming to prevent families from wasting hard earned time and money by avoiding the ER. I'm fascinated by what medicine could be in 10-20 years if we leverage smart design and technology the right away. Imagine a world where medicine came to you for prevention and for acute needs, and the hospital became an unfamiliar place we rarely visited outside of true emergencies.

Group: 1
Lead by: Igor Shumskiy, Nella Health Inc.

Future of Baby/ Kids Tech

As Statista estimates a $67 billion market for the baby space, there’s been a rise in digital health babytech companies, focusing on retail integration, wearbles, building communities, and interconnectivity with smart homes. This group discussion will give an overview of the industry’s past, showcase a few examples where it worked and doesn’t, discuss challenges, and predict trends of where babytech industry is heading.

Group: 2
Lead by: Jin Lee, BabyNoggin

Designer Calorie

With obesity being the national epidemic, my moon shot is to revolutionize this BMI anomaly trough genomics and implantables.

I envision redesigning the human genome and reprogramming their desires for food intake ( daily calorie intake ) in a way to match their precaloculated daily need for calorie intake by utilizing their personalized health data. Every human has a “personalized daily caloric capacity” matched exactly their personal caloric need. Once the capacity is reached their desire to eat is completely subsided.

We are revolutionizing the meaning of food.

In a longer term this would revolutionize the human’s behavior.

Group: 3
Lead by: Bahar Sedarati, Vital

Automotive Health

The future mobility bings us to a point where pharmacies and all kinds of services can come to our front door with an autonomous car. I'd like to have a discussion on this topic to get some other perspectives on it from other people.
From integrating oxygen capsules for cardiovascular prevention (the modern car already has all sensors to detect wether the heart is getting to less oxygen), to measuring breath gas for advanced analyzers up to building the basic ""store in the car for health services"" I'd love to get some input from others.

Group: 4
Lead by: Julian Weinert, AMBUALCNE Health Innovation Agengy GmbH

Regenerative Stem cell Therapy for Orthopedic and Spine conditions

I would like to foster a discussion about the latest in the use of stem cells for sports injuries and degenerative conditions of spine and joints, the challenges we face today and the medical and technology solutions that will help us obtain the best long term results.

Group: 5
Lead by: Annu Navani, Comprehensive Spine and Sports Center

How to facilitate discussion and cooperation between our Health Care startups and leading organizations

We at AI Startup Incubator support group of Health Care focused startups. They have global ambitions but Central European market limits their options. I would like to discuss cooperation possibilities with large organizations, for example on US market.

Group: 6
Lead by: Petr Sramek, AI Startup Incubator

DNA Personal Rights

Could I preserve my rights about my DNA? from the HeLa Cells to 23andme.com

Can we fight against this situation? What about if my DNA can change the history of healthcare?

Group: 7
Lead by: Juan Monzón, Exovite

Topical Sevoflurane for pain management in osteoarthritis and degenerative joint disease

Sevoflurane is a volatile liquid anesthetic that is used through inhalation for the induction and maintenance of general anesthesia. Our research group has 5 years of experience treating ulcers with topical sevoflurane and the results are very good, reducing the consumption of morphine. But what is really important here is the application of topical sevoflurane in healthy skin with the aim of treating pain in degenerative osteomuscular and articular pathologies. A gel made with a polymer that binds to sevoflurane forming a micelle structure, ensuring the permanence of the drug in the skin and making possible the analgesic action. We have patented microspheres to apply to patients in a patch over the painful area achieving an analgesic effect for the patient of 24-48-72 hours ... reducing opioid doses in patients. What applications have we achieved so far? So far, we have managed to treat osteoarthritis, skin ulcers, plantar fasciitis in marathon runners, sciatica pain.

Group: 8
Lead by: Dámaso Fernández Ginés, Torrecárdenas Hospital

Round Two

What medical apps do you use?

Discussion about what clinical medical smart phone apps you have installed and how you use them.

Group: 1
Lead by: Ron Schaefer, Hawai'i Pacific Health

Linking data analytics to real time user friendly decision support within the EHR

At my hospital there has been great success in implementing approximately 1000 clinical pathways and clinical decision support that clinicians find genuinely useful and want to use (45,000 hits last month).
We are trying to develop real-time data capture and analysis tools to feed directly into the decision tools and wish to collaborate with others on this.

Group: 2
Lead by: Martin Than, Christchurch Hospital New Zealand

AI for Biology and Precision Medicine: Deep Learning and Reasoning Computing

Applying AI to Biology and Medicine is the only way to scale research and manage its applications. Understanding how AI can be used is essential to prepare for the future. To address this challenge we must be able to deal both with Big Data and Complex Knowledge. Most of the attention today is on the Deep Learning approach that has revolutionized the way we can discover patterns from a set of Big Data. This is only half the story. The other half is using Reasoning Computing to process Complex Knowledge, in particular when humans have to deal with more than 5 to 9 concepts at the same time, as scientists and doctors have to do everyday. Understanding how these two approaches to AI are different and complementary is crucial to know how to apply them for any scientific challenges.

Group: 3
Lead by: Khai Pham, ThinkingNode, Inc.

CRISPR, Gene Editing Tool in Medicine

Jorge is a PhD that has been working with CRISPR for the last 4.5 years at the Doudna Lab. Learn with him how this tool can be applied to the future of Medicine and it’s new tools like CRISPR gold.

Group: 4
Lead by: Jorge Bardales, Nextbiotics

Brain - Machine Interface to Reanimate Paralyzed Limbs

Battelle has been conducting R&D research on brain-machine interfaces to reanimate paralyzed limbs. This presentation will describe the goals of the program and the results achieved to date with our first in-man patient.

There is a fantastic video produced by Facebook that describes the research program

Group: 5
Lead by: David Giles, Battelle

Preventive exponential framework for the developing world

Translating scientific wellness in preventive healthcare to improve outcomes and reduce cost in the developing world. This segment will benefit the most but are least equipped to benefit from the exponential progress herein.

Group: 6
Lead by: Esai Umenei, Amway

Adoptive Radioisotope Immuno Therapies - The Paradigm Shift in Precision Oncology

Trageted Radioisotope Therpies and Diagnostics (combined theranostics) are beginning to change the landscape in Oncology. The combination of next generation isotope platform for imaging and therapy (Lu-177, Ac-225, Ga-68 etc) with advances in bio-molecular targeting are now leading to an exponential growth in both global clinical applications and patient numbers. Several therapies are now already either in late clinical development stages or showing fundamentally improved results in various cancers such as Neuroendocrine, pancreatic, bone, kidney, brain and other cancers. Improvements in progression free survival are measure in years rather than months while undesired sideeffects are drastically minimized retaining full quality of life for the patients. The financial markets recently also have started to acknowledge the value of these new platforms as illustrated by several recent high profile transactions, IPOs and the the take-over bid of Novartis for Advanced Accellerator Applications at 3.9Bn. The Topic will cover the basics of Molecular Targeted Isotope Therapies and Diagnostics in Precision Oncology, the patient continuum and value proposition when combined with Precision Diagnostics such as Liquid Biopsies and the fundamental health economic impact on cancer management.

Group: 7
Lead by: Oliver Buck, ITM Isotope Technologies Munich AG

Evolution of the provider-people relationship

Is technology strengthening or weakening the relationship between people and their doctor? The days of a family doctor who would come to your house and care for generations gave way to layers of care providers. Connections with people and their doctors became more challenging to maintain. Are we heading toward bridging these relationships or are we continuing to erode?

Group: 8
Lead by: Sandeep Pulim

Round Three

EntrepreNURSE: Nurses disrupting healthcare

Ranked as the most trusted professional in the United States, nurses, at nearly 4 Million strong, represent the largest segment of healthcare professionals. Shockingly, they are significantly under-represented in boardrooms, product design and innovation initiatives despite being the end user of nearly every healthcare tool. Join us to discuss how to actively engage nurses at the bedside and beyond in innovation and improvements in healthcare - helping not only to shape the future of healthcare innovation but also to redesign the fundamental thinking of nursing education, which teaches nurses a wonderful clinical toolbox, but not the busies of healthcare. Installing and supporting the fundamental principals of innovation and entrepreneurship teaches to nurses could dramatically impact the outcomes and landscape of healthcare - meet to discuss how we shape this conversation!

Group: 1
Lead by: Rebecca Love, Northeastern University

How to Leverage Music and Neuroscience to change mental health

Music affects people deeply. Can we leverage what we know about music combined with Neuroscience to dramatically reduce anxiety, depression and positively impact mental health.

Group: 2
Lead by: Terry Stuart, Deloitte

Crowdsourcing the Cannabis Scientific Renaissance

Join Jeff Chen MD/MBA, Director of the UCLA Cannabis Research Initiative, on a journey to Crowdsourcing the Cannabis Scientific Renaissance.

Despite 29 states and the District of Columbia legalizing cannabis for medical or recreational use, cannabis still remains a "Schedule 1 Drug" alongside substances like heroin and LSD. This designation has prevented research for nearly a century.

The therapeutic potential of cannabis is immense--it could be a cheap, safe, effective treatment for a variety of disorders, ranging from cancer and inflammation to chronic pain and neurodegenerative diseases. Cannabis' compounds mimic the endocannabinoids our bodies naturally make, and disruptions in the endocannabinoid system are implication in virtually all chronic diseases affecting humans.

Unfortunately, cannabis is the most difficult substance to study in America-- there are massive hurdles researchers must navigate, and no traditional funding sources for therapeutic research on Schedule 1 Drugs. How are we supposed to do more with less? Luckily there is an unprecedented opportunity to create one of the largest crowdsourced health studies ever conducted. There are nearly 30 million Americans using cannabis on a regular basis. We can leverage smartphones, wearables, EHRs, and artificial intelligence to drive insights into the benefits and risks of cannabis use.

Group: 3
Lead by: Jeff Chen, UCLA Cannabis Research Initiative

Wearable and Embedded Medical Sensors in Restrictive Environments

For those in the military, especially in the Navy, the future of wearable and embedded medical sensors is problematic. These sensors will need to connect to networks via wireless communications and that may not be possible in ships or submarines due to physical and security restrictions. Similarly, those who work in environments with restrictive security requirements, such as intelligence agencies, may not be allowed to have these medical sensors on or in their bodies. So are they to be denied the advances that exponential medicine may offer due to their chosen profession? Mitigating strategies and technologies need to be developed so that these people can benefit from what modern technology offers.

Group: 4
Lead by: Gary Burnette, Space and Naval Warfare Systems Center Pacific

Med Device Innovation in Academia – Entrepreneurship in the Publish-or-Perish Paradigm

Academic scientists employed at traditional universities are professionally incentivized to discover new things and write about them, with commercialization and entrepreneurship as an afterthought at best (strongly discouraged at worst). Commercialization of an idea requires capitalistic thinking, which involves comparing market size with the cost of bringing a product to market. Scientists who want their ideas to go beyond publication and mature into products for the benefit of humankind must think of the entire pathway to commercialization at the ideation the stage. Further, when academics choose to embark on the entrepreneurial journey they must understand two things: a) large portions of their day-to-day activity will not count toward academic promotion, and b) to bring their idea to the point where it helps society might require a departure from traditional academia. In this xMed UnConference session, we explore several examples of entrepreneur-scientists and how they developed their ideas into real products. Case examples of translation of science to product will be discussed. Audience attendees will gain an understanding of the commitment required, and extraordinary personal and professional satisfaction, that comes from academic entrepreneurship.

Group: 5
Lead by: Matt Maltese, The Children's Hospital of Philadelphia / University of Pennsylvania

Evidence-based Healthspan Extension: Adding Healthy Years to Human Life

Over the last two decades, numerous evolutionarily conserved pathways that regulate longevity have been identified in several model systems such as yeast, fruit flies, worms, and mice. Modifications of these pathways either genetically or pharmacologically have been shown to extend the lifespan of these model organisms. The majority of pharmacological intervention studies have focused on lifespan extension and very little attention has been given to the concept of healthspan extension. In our discussion, we will explore ideas on the current evidence based interventions that can increase healthspan and the future of healthspan extension.

Group: 6
Lead by: Mahtab Jafari, University of California, Irvine

Solar energy can eliminate our number one public health challenge: Global Warming

The Americans public Health Association has called global warming perhaps our number one public health threat due to increasing natural disasters and the threat of widespread disease outbreaks. This week a major US government report confirms global warming at an alarming rate. By the end of century the ocean level may rise by 5-7 inches creating crises around the world.

Our moonshot is to convert the world’s energy grid to solar thereby reversing global warming using a recently patented breakthrough exponential CSP solar technology that promises to make solar cheaper than coal. Our community has a critical role to play in bringing this technology to light and reversing global warming.

Group: 7
Lead by: Jeff Gruen, Dimerond

Internet base donation plataform

How to increase, facilitate, secure and exponentiate the act of donation.

Group: 8
Lead by: Danilo Soriano, Conecte os Pontos

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What is UnConference?

This is a chance to join your fellow participants in a refreshing, peer-to-peer discussion.

Rather than a lecture or panel, an UnConference allows you to propose ideas, topics, or questions for presentation and discussion amongst yourselves.

Submit a topic using the form to the left. If selected, you will set the tone and facilitate a discussion. You must be prepared to engage the group and allow other attendees to participate as equals.

Note this is not meant to be a sales presentation, so please avoid excessive self-promotion.

UnConference participants vote with their attention, and with their feet. If the discussion doesn’t interest them, any participant can move on to a different discussion.

Questions? Send us an email at [email protected]